Homology Searching and Interlocking of Chromosomes: Analytic Modeling versus Computer Simulation
نویسندگان
چکیده
In order to simulate the process of homology searching and interlocking of chromosomes in meiotic pairing, a cellular automaton model is introduced. The model reflects both the spatial as well as the temporal behavior of chromosomes in the meiotic cell nucleus. Moreover, we compare the outcome of our simulations to results obtained by a stochastic model describing interlocking probabilities analytically. With the stochastic model we use our simulation results to estimate model parameters. Thus a far more general description of chromosomal behavior is achieved which relies on both simulation and analytic considerations. AMS Subject Classification: 92C37, 37N25, 60J10
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